New TCO Reagents for Fast Bioorthogonal Conjugation
Lumiprobe has recently expanded its bioconjugation reagent portfolio with a new range of cycloalkene-functionalized TCO (trans-Cyclooctene) reagents designed for bioorthogonal inverse electron-demand Diels–Alder (IEDDA) cycloaddition reactions.
TCO derivatives react rapidly and selectively with tetrazines without requiring a catalyst. These reagents are suitable for a variety of applications, including biomolecule conjugation, fluorescent labeling, antibody and protein conjugate preparation, live-cell studies, and in vivo applications.
The newly introduced fluorescent TCO derivatives include AF, Cyanine, sulfo-Cyanine, and BDP® dyes, providing a range of fluorescent options for different spectral and bioimaging applications.
New Fluorescent TCO Reagents
| Product | Features |
|---|---|
| BDP® FL TCO | A bright and photostable fluorescent dye suitable for the FAM channel |
| AF 568 TCO | A bright and photostable orange fluorescent dye |
| AF 647 TCO | A bright, hydrophilic far-red fluorescent dye |
| Cyanine3B TCO | A TCO derivative of the bright yellow Cyanine3B fluorescent dye |
| sulfo-Cyanine5 TCO | A water-soluble far-red fluorescent dye |
| sulfo-Cyanine7 TCO | A bright near-infrared (NIR) fluorescent dye |
Key Features of TCO Reagents
- One of the fastest bioorthogonal reactions available
- No catalyst required
- High selectivity with minimal interaction with biological components
- Compatible with live cells and sensitive biomolecules
- A range of fluorescent derivatives for diverse bioconjugation, fluorescent labeling, and bioimaging applications
These new products are now available as part of Lumiprobe's Cycloalkenes product range.
For product inquiries or further information, please feel free to contact us.